October 15, 2018

Erin presented The Role of Immune Inhibitor A1 Metalloprotease in Bacillus Intraocular Infection at the International Conference on Gram-Positive Pathogens in Omaha NE. She also won a travel award! Congratulations Erin!

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October 9, 2018

Mursalin presented Role of Bacillus S-Layer Protein in Host-Cell Interactions During Endophthalmitis to the OUHSC Microbiology and Immunology Department today. Great job Mursalin!

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September 6, 2018

We’re excited to announce that our R01 proposal on Bacillus endophthalmitis pathogenesis was funded by NEI/NIH for 5 years. Way to go Phil, Kris, Erin, Mursalin, Roger, Austin, Omar, Morgan, Anna, Parth, Daniel, and Caleb! Hard work by a fantastic group of scientists pays off!

August 2018

We’re on Twitter! @CalleganLab

July 24, 2018

Erin was presented with a Society for Leukocyte Biology Trainee Award today by Dr. Darren Lee. Congratulations Erin!!!  

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July 2, 2018

Congratulations Erin on passing your General Exam!

June 18, 2018

Dr. Callegan gave an invited talk at the World Ophthalmology Congress in Barcelona, Spain entitled Novel Strategies for Combating Antibiotic Resistance in Eye Infections. 

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June 9, 2018

Mursalin presented Contribution of S-Layer to the Pathgenesis of Bacillus Endophthalmitis (Mursalin, Coburn, Arroz, Miller, Astley, Fouet, and Callegan) at the American Society for Microbiology 2018 Annual Meeting, Atlanta GA.

Mursalin also won an ASM Travel Award for his poster!

 

 

June 1, 2018

Welcome back to the Summer Crew…Austin LaGrow (OUHSC Medical Student), Parth Patel (Oklahoma School for Science and Math), Daniel Astley (University of Central Oklahoma), Caleb Astley (Deer Creek/Francis Tuttle), and Anna Gregory (Teacher at U.S. Grant High School).

April 29, 2018

Dr. Callegan presented Efficacy of Nanosponges in Protecting Retinal Function During Bacterial Endophthalmitis (Callegan, Coburn, Miller, LaGrow, Land, Chen, Gao, and Zhang) at the Association for Research in Vision and Ophthalmology 2018 Annual Meeting, Honolulu HI.

April 28, 2018

Dr. Callegan presented Mentoring vs. Sponsorship at the Leadership Development Program for Women at the Association for Research in Vision and Ophthalmology 2018 Annual Meeting, Honolulu HI.

April 23, 2018

Dr. Callegan was named a George Lynn Cross Research Professor at the OUHSC College of Medicine Spring Faculty Awards ceremony today. This professorship is the highest distinction for research for OUHSC faculty and carries the lifetime title of George Lynn Cross Research Professor.

On November 12, 1943 the Board of Regents established the Regents’ Professorship.  Upon his retirement from the University in 1968 the Regents named this professorship after George Lynn Cross. To qualify for a George Lynn Cross Research Professorship, a faculty member must have demonstrated outstanding leadership over a period of years in his or her field of learning or creative activity and have been recognized by peers for distinguished contributions to knowledge or distinguished creative work. The term of a George Lynn Cross Research Professor is continuous until retirement. —From facultyawards.ouhsc.edu

April 12, 2018

Mursalin was the Flash Talk Session 1 Winner at the OUHSC GREAT Symposium for his flash talk presentation of Contribution of S-Layer to the Pathogenesis of Bacillus  Endophthalmitis. Congratulations Mursalin!!!

April 11, 2018

New publication! Coburn PS, Miller FC, LaGrow AL, Parkunan SM, Randall CB, Staats RL, Callegan MC. TLR4 modulates inflammatory gene targets in the retina during Bacillus cereus endophthalmitis. BMC Ophthalmology BOPH-D-17-00549R4 Accepted 4/3/18. Online 4/17/18.

Link

April 6, 2018

Dr. Callegan presented Host/Pathogen Battles in Bacterial Intraocular Infections to Sophomore and Senior Biology students at Oklahoma Christian University.

March 30, 2018

Mursalin was awarded a Travel Grant to ASM Microbe 2018 in Atlanta. Congratulations Mursalin!!!

March 21, 2018

Erin was accepted as a 2018 NEI Vision Science Pre-Doctoral Trainee for the DMEI/OUHSC/OMRF Vision Science Training Program (T32)! Congratulations Erin!!!

March 14, 2018

Mursalin presented his first departmental seminar in Microbiology and Immunology. His seminar was titled Contribution of S-Layer to the Pathogenesis of Bacillus  Endophthalmitis.

February 26, 2018

Dr. Callegan presented Host/Pathogen Battles in Bacterial Intraocular Infections at Oklahoma State University’s Department of Microbiology and Molecular Genetics.

December 11, 2017

A figure from our recent mSphere paper was chosen as the Cover Image for November/December.

Link

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November 28, 2017

New Publication! LaGrow AL, Coburn PS, Miller FC, Land C, Parkunan SM, Luk BT, Gao W, Zhang L, Callegan MC. A novel biomimetic nanosponge protects the retina from the Enterococcus faecalis cytolysin. mSphere 2017;e00335-17.

Link

November 22, 2017

Our new mSphere paper is featured in Science Daily.

American Society for Microbiology. “Nanosponges show promise for potentially blinding eye infections.” ScienceDaily, 22 November 2017.

Link

November 7, 2017

Erin has been accepted as an NEI Vision Science Pre-Doctoral Trainee for the DMEI/OUHSC/OMRF Vision Science Training Program (T32)! Congratulations Erin!!!

September 29, 2017

At the 11th Annual OU Vision Student and Postdoctoral Fellow Workshop, Erin presented Characterization of PMN Dysfunction During Bacillus cereus Endophthalmitis and Mursalin presented Unconventional Toll-like Receptor 4 (TLR4) Agonists in Gram-positive Bacillus cereus.

August 10, 2017

Congratulations Mursalin on passing your General Exam!

July 2017

Our lab is featured in the spring/summer edition of OU Medicine.

Link

June 9, 2017

An official welcome to the Summer Crew…Ty Dilley (OUHSC Medical Student), Austin LaGrow (OUHSC Medical Student), Melissa Penton (INBRE Student from East Central University), Parth Patel (Oklahoma School for Science and Math), Daniel Astley (University of Central Oklahoma), Caleb Astley (Deer Creek/Francis Tuttle), and Emma Howard (Edmond Memorial).

June 2-3, 2017

At ASM Microbe 2017 in New Orleans, Dr. Coburn presented A Novel Biomimetic Nanosponge Protects the Retina from the Enterococcus faecalis Cytolysin (Coburn, LaGrow, Miller, Luk, Zhang, Callegan), and Dr. Callegan presented Transcriptome Analysis of Bacillus cereus in Ocular and Laboratory Environments (Callegan, Coburn, Enty, Land, LaGrow, Miller).

May 26, 2017

New Publications photo: A portion of a heat map of the transcriptomes of B. cereus cultivated in ocular and laboratory environments. This data will be presented next week at ASM in New Orleans. Illumina MiSeq Next Gen sequencing was performed and data analyzed with the CLC Genomics Workbench (Qiagen) at the OUHSC Laboratory for Molecular Biology and Cytometry Research.

May 7, 2017

Dr. Coburn was a co-author on the following presentation: Bhatti F, Kassa N, Kung J, Coburn P. Effect of Surfactant Protein A on Retinal Cytokines and Microglia in Systemic Inflammation. Association for Research in Vision and Ophthalmology 2017 Annual Meeting, Baltimore MD.

May 5, 2017

Dr. Callegan presented Messaging Yourself: Increasing Your Visibility & Crafting Your Message and Maximizing Your MPG (Mission-Planning-Goals) at the Leadership Development Program for Women at the Association for Research in Vision and Ophthalmology 2017 Annual Meeting, Baltimore MD.

May 1, 2017

An official welcome to Erin Arroz, Graduate Student in the Department of Microbiology and Immunology, to the lab!

March 20, 2017

New Publication!

Callegan MC, Parkunan SM, Randall CB, Coburn PS, Miller FC, LaGrow AL, Astley RA, Land C, Oh S-Y, Schneewind O. The Role of Pili in Bacillus cereus Intraocular Infection. Exp Eye Res 159:69-76, 2017.

Link

March 8, 2017

New News photo courtesy of Craig Land, Dr. Coburn, and the Oklahoma Medical Research Foundation Imaging Core. Bacillus cereus flagella, 50,000X magnification.

February 8, 2017

Dr. Callegan presented Endogenous Endophthalmitis: The Beast Within at Asia-ARVO 2017 in Brisbane.

October 14, 2016

Mursalin presented Sex as a Biological Variable in Gram-Positive Endophthalmitis at the 10th Annual OU Vision Student & Postdoctoral Fellow Workshop.

September 20, 2016

Dr. Callegan presented Bacterial Endophthalmitis: BOB’s Your Uncle at the Department of Microbiology and Immunology’s Seminar Series

July 15, 2016

Sujana presented A Novel Biomimetic Nanosponge Protects the Retina from the Enterococcus faecalis Cytolysin at the Oklahoma IDeA Network for Biomedical Research Excellence (OK-INBRE) Summer Research Program’s final poster session.

July 13, 2016

We held our Lab Retreat today at the Oklahoma City Zoo Treehouse. Great meeting facilities. Everyone presented their summer projects and research plans for the next year. A little bit of Poke-hunting and a lot of great science at the OKC Zoo!


Dr. Miller, Mursalin, Daniel, Haley, Craig, Sujana, Austin, Dr. Coburn, Dr. Callegan, Morgan, and Roger.

June 12, 2016

New publication!
Parkunan SM, Randall CB, Astley RA, Furtado GC, Lira SA, Callegan MC. CXCL1, but not IL-6, significantly impacts intraocular inflammation during infection. J Leukocyte Biol 2016.
In press

June 1, 2016

An official welcome to the Summer Crew…Morgan Enty (OUHSC Medical Student), Victoria Smith (OUHSC Medical Student), Sujana Rupakheti (INBRE Student from Cameron University), Meghna Shankar (Baylor University), Daniel Astley, and Haley Callegan…and a bittersweet “see you later” (never goodbye!) to Dr. Madhu Parkunan and Nanette Wheatley Albrecht.

May 20, 2016

New publication!
Coburn PS, Wiskur BJ, Miller FC, LaGrow AL, Astley RA, Elliott MH, Callegan MC. Bloodstream-To-Eye Infections Are Facilitated by Outer Blood-Retinal Barrier Dysfunction. Plos One 2016.
In press

May 13-14, 2016
The typical Oklahoma stormy weather disrupted the graduation festivities in Norman on the 13th, but Madhu was hooded by Dr. Callegan the next day at the OUHSC Graduate College Convocation. Dr. Parkunan’s Ph.D. thesis is titled “Contribution of Host Innate Responses to the Pathogenesis of Bacillus cereus Endophthalmitis”. Her thesis contains her three first-author papers in 2014, 2015, and 2016. Congratulations Dr. Salai Madhumathi Arasi Parkunan!

May 5, 2016

New publication!
Astley RA, Coburn PS, Parkunan SM, Callegan MC. Modeling intraocular bacterial infections. Prog Retina Eye Res 2016.
In press online version

May 2, 2016

The following research was presented today at ARVO 2016 in Seattle:
Coburn PS, Miller FC, Land C, LaGrow AL, Callegan MC. Cereolysin O influences TLR4-dependent retinal gene expression during Bacillus cereus endophthalmitis.
Callegan MC, Coburn PS, Zhao H, Rybenkov VV. Role of Pseudomonas aeruginosa Condensins in Corneal Infection.

April 30, 2016
Dr. Callegan gave a talk entitled Mentorship and Sponsorship at the ARVO Women’s Leadership Development Program in Seattle.

April 28, 2016
Madhu successfully defended her Ph.D. Dissertation!
CONGRATULATIONS DR. PARKUNAN!

April 24, 2016
New publication! Parkunan SM and Callegan MC. The Pathogenesis of Bacterial Endophthalmitis. In Endophthalmitis, Durand, Miller, and Young eds. Springer International Publishing Switzerland. 2016

http://www.springer.com/jp/book/9783319292298

April 1, 2016
New publication in American Journal of Ophthalmology Case Reports
Venincasa VD, Callegan MC, Astley RA, Siatkowski RM. Contact Lens-related Polymicrobial Keratitis from Pantoea agglomerans and Escherichia vulneris. Am J Ophthalmol Case Rep (2016, in press). NIH Public Access Compliance: In process at NIHMS [NIHMS771299].

March 9, 2016
An official welcome to MD Huzzatul Mursalin, graduate student in the Department of Microbiology and Immunology, to the lab!

March 2, 2016
Welcome to our new website!